Addiction: Childhood Trauma, Stress and the Biology of Addiction

Abstract Rather than choice, chance or genetic predetermination, it is childhood adversity that creates the susceptibility for addiction. Humans and animals require nurturing from a caregiver in order to survive, When a child does not receive consistent, secure interactions, or experiences painfully stressing ones, maldevelopment results. In vivo studies have…

Iodine Supplementation and Monitoring to Ensure Patient Health and Safety

Abstract Iodine deficiency is a leading cause of thyroid disorders. Deficiency can manifest as hypothyroidism, goiter, or impaired mental function. Insufficient levels of iodine increase the risk of thyroid cancer and may be associated with risk of breast, ovarian, endometrial, stomach, and esophageal cancer. In an effort to address iodine…

Glutathione: Physiological and Clinical Relevance

Abstract Glutathione (GSH), the most abundant intracellular low molecular weight thiol, has diverse physiological roles, and altered GSH status has been implicated in a number of chronic, acute, and age-related diseases, as well as the aging process itself. Its function as an antioxidant and determinant of cellular redox potential is…

Vitamin D and Major Chronic Illness

Abstract OBJECTIVE: To review the current literature regarding vitamin D insufficiency and supplementation in major illnesses. DESIGN AND METHODS: We reviewed Pubmed-indexed, English language manuscripts from January, 2003 to June, 2012 using search terms related to vitamin D, all-cause mortality, cardiovascular disease, pulmonary disease, diabetes mellitus, and cancer. OUTCOME MEASURES:…

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