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Peer-reviewed journal articles on latest research.

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Read the Journal of Restorative Medicine

We provide cross-disciplinary medical education on treating endocrine system disorders and other chronic diseases with herbal, nutritional, and hormone medicines.

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Recent Journal Articles

The Association of Vitamin D Status and Pre-operative Physical Activity in Patients with Hip or Knee Osteoarthritis

Osteoarthritis (OA) afflicts over 12 million elderly Americans and is one of the leading causes of disability amongst non-institutionalized adults. It often leads to decreased mobility, lower functional status, and reduced quality-of-life (QoL). Conservative management of OA includes avoidance of high-impact activities, weight loss, non-steroidal anti-inflammatory drugs (NSAIDs), glucosamine/chondroitin supplements, and physical therapy. When such management is no longer effective, joint replacement surgery may be offered to patients to alleviate pain, optimize function, and improve QoL.

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This is our most exciting issue to date. We continue our mission to bring you the most relevant clinical information and concepts regarding restorative medicine. We begin this issue with several original research articles in the areas of bone health, inflammation, and prostate cancer. Sadeq Quraishi, MD, MHA, MMSc, Elizabeth Jacob, BA, Livnat Blum, BA, Hany Bedair, MD, and Andrew Freiberg, MD, present an NIH-funded study looking at the association of vitamin D status and pre-operative physical activity in patients with hip or knee osteoarthritis. The authors show that vitamin D levels were associated with pre-operative physical activity scores, in the hopes of paving the way for prospective, randomized clinical trials.

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Thyroid Hormones and their Thermogenic Properties

Obesity is a major issue in developed countries. Regulating thyroid hormones is a growingly popular adjunct in a comprehensive approach towards weight loss. Despite growing popularity, there is a lack of knowledge about underlying pathways. This review investigates the thermogenic properties of thyroid hormone on brown adipose tissue (BAT), white adipose tissue (WAT) and the hypothalamus. Current evidence about potential inducers of thermogenesis and potential clinical implications for weight loss are explored.

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The Role of Selenium in Thyroid Autoimmunity: A Review

Autoimmune thyroid diseases, including Graves’ disease and Hashimoto’s thyroiditis, are the most common autoimmune conditions in humans. There is significant morbidity associated with thyroid autoimmunity, and typically ongoing management is required to control disease presentation and reduce sequelae. Thyroid tissues contain the highest concentration of selenium in the body, owing to selenium’s crucial role in glutathione peroxidases, thioredoxin reductases, and iodothryonine deiodinases. Selenium deficiency is associated with sub-optimal thyroid function, and has been shown to be a risk factor for both Hashimoto’s thyroiditis and Graves’ disease. As a therapeutic intervention, selenium has been shown in a number of studies to reduce thyroid antibodies, although there remains limited information regarding its impact on clinical outcomes. In Graves’ disease, and specifically in Graves’ ophthalmopathy, selenium appears to play a beneficial role in altering disease progression and improving ophthalmic symptoms. The various functions of selenium in thyroid autoimmunity are reviewed.

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