The need for safe and effective therapies to promote cognitive health, and the growing interest in healthy longevity have brought the therapeutic promise of neuropeptides increasingly to the forefront of restorative medicine practice. read more »
An emerging direction of research focuses on the gut microbiome as a complex, metabolically active system whose metabolites can impact the development of cardiometabolic diseases by directly influencing the phenotype of the host. read more »
A growing body of evidence shows that susceptibility to adult-onset CVD begins in early life, even in utero, presumably as a result of epigenetic dysregulation. read more »
Over time, increased hemodynamic stress on the heart from high blood pressure leads to the compensatory development of left ventricular hypertrophy. read more »
Mounting evidence suggests that some viruses can persist in heart tissue after an initial infection, and become reactivated under certain conditions, triggering a cell-mediated immune response that leads to myocarditis and, potentially, dilated cardiomyopathy. read more »
TUDCA is safe and potentially effective in ALS, which is now the first neurodegenerative condition to be treated with hydrophilic bile acids. read more »
Fisetin has been shown to have a positive effect on the complex array of interconnected signaling mechanisms that play a key role in regulating aging and health. read more »
Efforts to prevent senescence resulting from cancer treatment have led to the emerging field of senolytic drug development. The goal of potential senolytic drugs is to induce apoptosis in tumor cells or inhibit expression of the senescence-associated secretory phenotype (SASP). read more »
The link between viral infections and cellular senescence has prompted researchers to investigate the efficacy of senolytic agents, which have been shown to induce apoptosis in senescent cells. read more »
Both pre-clinical and clinical studies continue to shed light on berberine’s therapeutic potential, corroborating many of its traditional uses. read more »