Restorative Medicine Digest

Quarterly Newsletter
Restorative Medicine Digest

Lifestyle Factors and Cardiovascular Health: The Gut-Heart Axis

An emerging direction of research focuses on the gut microbiome as a complex, metabolically active system whose metabolites can impact the development of cardiometabolic diseases by directly influencing the phenotype of the host. read more »

Genetics and Genomics in Cardiovascular Health Risk: It’s Complicated

A growing body of evidence shows that susceptibility to adult-onset CVD begins in early life, even in utero, presumably as a result of epigenetic dysregulation. read more »

High Blood Pressure: A Major Risk Factor for Heart Failure

Over time, increased hemodynamic stress on the heart from high blood pressure leads to the compensatory development of left ventricular hypertrophy. read more »

The Role of Viral Infection in Heart Failure

Mounting evidence suggests that some viruses can persist in heart tissue after an initial infection, and become reactivated under certain conditions, triggering a cell-mediated immune response that leads to myocarditis and, potentially, dilated cardiomyopathy. read more »

TUDCA and Neurodegeneration

TUDCA is safe and potentially effective in ALS, which is now the first neurodegenerative condition to be treated with hydrophilic bile acids. read more »

Fisetin and Lung Health

Fisetin has been shown to have a positive effect on the complex array of interconnected signaling mechanisms that play a key role in regulating aging and health. read more »

Senolytic Therapy and Cancer

Efforts to prevent senescence resulting from cancer treatment have led to the emerging field of senolytic drug development. The goal of potential senolytic drugs is to induce apoptosis in tumor cells or inhibit expression of the senescence-associated secretory phenotype (SASP). read more »

A Novel Role for Senolytic Therapies

The link between viral infections and cellular senescence has prompted researchers to investigate the efficacy of senolytic agents, which have been shown to induce apoptosis in senescent cells. read more »

Berberine in Cardiovascular and Metabolic Health

Both pre-clinical and clinical studies continue to shed light on berberine’s therapeutic potential, corroborating many of its traditional uses. read more »

Cardiovascular Health Update: Red Yeast Rice

Studies have shown that daily consumption of Red Yeast Rice lowers plasma levels of LDL cholesterol by 15-25% within six to eight weeks. read more »