2022 Peptide Course

On Demand — Online

Peptide/Stem Cell Intensive is presented by Dr. Edwin Lee, MD, FACE & Dr. Luis Martinez, MD, MPH.

Neurology Seminar

2022 Peptide Course – Schedule

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On Demand - Recordings available now

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On Demand Peptide Course

Time / period
All times are in EDT
Session
Edwin Lee, MD Introduction to Peptides (Recording)
Edwin Lee, MD Neuroregenerative Peptides (Recording)
Edwin Lee, MD Increasing Growth Hormone with Peptides (Recording)
Edwin Lee, MD Peptides for Hair Growth (Recording)
Luis Martinez, MD, MPH Peptides in Autoimmune Diseases (Recording)
Luis Martinez, MD, MPH Metabolic Peptides (Recording)
Edwin Lee, MD The Healing Peptide BPC 157 (Recording)
Edwin Lee, MD Cosmeceutical Peptides (Recording)
Luis Martinez, MD, MPH Peptides in Cancer Treatment (Recording)
Edwin Lee, MD & Luis Martinez MD Top 5 Peptides and Peptide QA (Recording)

On Demand, Peptide Course

Time / period
All times are in EDT
Session
Luis Martinez, MD, MPH Immunosenescence
Edwin Lee, MD Understanding Senescence and Senolytic Therapy
Luis Martinez, MD, MPH Peptides in Athletic Performance (Recording)
Edwin Lee, MD Controversy of Insulin Growth Factor –1 (IGF–1) and longevity
Edwin Lee, MD Peptides for Pain (Recording)
Luis Martinez, MD, MPH Nuts and Bolts in Stem Cells
Edwin Lee, MD: Case Studies of Peptides, Stem Cells and Senolytic Therapy (Recording)

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13 CME Credits

Earn up to 13 CME. Credit approval through AAFP, OBNM, CONO & PACE.

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If you have a question or problem registering, please email conferences@restorativemedicine.com or call toll-free 866-962-2276

 

 

Sessions

Increasing Growth Hormone with Peptides

Edwin Lee, MD, FACE

Growth hormone is an essential hormone in lowering body fat, improving on lipids, keeping muscles healthy and improving on bone density. Unfortunately, the treatment with recombinant human growth hormone is not covered under most insurance plans and also it is expensive for most people to pay cash for. There is an alternative to the expensive recombinant human growth hormone mostly commonly used for boosting IGF-1 and has the advantage of inducing all five of the hGH isoforms, rather just the one that is found in the synthetic form. CJC-1295, Ipamorelin and Tesamorelin are peptides that have been shown to help improve IGF-1 levels. Other growth hormone releasing peptides will be reviewed.

Course Objectives:

  • Recognize which peptides interact between the two receptor sites of the pituitary GHRH receptor and Ghrelin receptor in increasing growth hormone.
  • Recognize the other benefits of the growth hormone releasing peptides.
  • Understand how to dose the growth hormone releasing peptides.

Introduction to Peptides

Edwin Lee, MD, FACE

The world of peptides therapy is a growing field in medicine, ranging from improving skin care and growth hormone, to bettering one’s immune system, to name a few. On PubMed there are more than 2.5 million articles on peptides. Peptides are small proteins that have unique regenerative properties. Peptides have been discovered since the 1960s and many countries offer peptides in their health care system. It is estimated that humans have over 250,000 peptides and we only understand a fraction of them. Peptides are chains of amino acids linked together by a polypeptide bond. How peptides are synthesized in a lab will be reviewed. Because many peptides can be obtained inexpensively on the Internet, the importance of obtaining peptides from a reputable compound pharmacy will be reviewed. In addition, the mechanism of action on how peptides work will be covered. A case study of a neuroregenerative peptide will be reviewed.

Course Objectives:

  • Describe what a peptide is
  • Understand how a peptide is synthesized.
  • Understand on which type of receptor is activated with a peptide

Neuroregenerative Peptides

Edwin Lee, MD, FACE

Neurodegenerative diseases affect millions of people worldwide. Alzheimer’s disease and Parkinson’s disease are the most common neurodegenerative diseases. In 2016, approximately 5.4 million Americans were living with Alzheimer’s disease.

Neurodegenerative diseases occur when nerve cells in the brain or peripheral nervous system lose function over time and ultimately die. In this lecture regenerative peptides for the brain will be reviewed. Some peptides have been shown to increase Brain Derived Neurotrophic Factor (BDNF) to help with nerve cell regeneration. It is noted that patients with Alzheimer’s have low BDNF and improving BDNF can help with cognition. Other pathways will be discussed in improving cognition.

Course Objectives:

  • Discuss peptides effects on Brain Derived Neurotrophic Factor
  • Review regenerative peptides for the brain.
  • Formulate a plan to help with improving cognition.

Peptides for Hair Growth

Edwin Lee, MD, FACE
According to a 2014 survey by the International Society of Hair Restoration, approximately 35 million men in the United States suffer some type of hair loss, and approximately 21 million women are affected by hair loss. There are peptides to help with hair growth and to help with new hair follicles. The hair cycle and the causes for hair loss will be reviewed. The WNT pathway is a critical factor for hair growth and the discovery of the CXXC5 protein that is responsible for hair loss will be reviewed. Peptides that will be covered Thymulin, GHK copper, PTD and Thymosin Beta 4.

Course Objectives:

  • Describe the hair cycle and the causes of hair loss
  • Review of evidence-based studies with peptides on hair growth
  • Formulate a plan on peptides for hair growth.

Peptides in Autoimmune Diseases

Luis Martinez, MD, MPH
Millions of Americans suffer from autoimmune diseases. Immune dysregulation, a universal characteristic of autoimmune diseases, can be targeted through the use of specific peptides. The pathophysiology of autoimmunity will be reviewed. The lecture will also present the rationale for utilizing peptide therapy in the management of autoimmune diseases. T cell modulation, cell predominant shifts, OGF axis and other mechanisms of action will be highlighted. VIP, thymosins and other peptides will be covered. Cases and protocols will be discussed.

Course Objectives:

  • Define immune dysregulation in autoimmune diseases
  • Review TH1/TH2/TH17 alterations and their impact
  • Detail specific peptides and their mechanisms of action

Metabolic Peptides

Luis Martinez, MD, MPH
Metabolic optimization and its sequelae (weight loss, maintenance of lean muscle mass, cardiometabolic fitness) remains a challenge for many patients. This lecture will discuss how peptides can be used to improve metabolism. We will discuss master pathways involved in food intake and metabolism as well as growth hormone axis and how it relates to metabolic optimization. Novel peptides such as MOTS-C will be discussed. Mitochondrial dysfunction and optimization will be highlighted as part of an overall strategy for improving metabolism.

Course Objectives:

  • Review pathways involved in feeding and metabolism
  • Detail mitochondrial function, or lack thereof, and how this impacts metabolism
  • Detail multiple peptides which can be integrated as a strategy for improving metabolism

The Healing Peptide BPC 157

Edwin Lee, MD, FACE
BPC-157 most likely has been used in humans for over 120 years from the discovery of gastric juice (which most likely had BPC-157) by Dr. Pavlov. It was not until Dr. Predrag Sikiric discovered BPC 157 in 1993 that we have a lot of clinical data of the regenerative properties of BPC-157 in animals. BPC-157 has an amazing healing peptide from reducing inflammation, increasing the production of type 1 collagen, improving the lower esophageal sphincter, healing fistulas and helping with repairing many parts of our body. Published studies of BPC-157 will be reviewed. Dosing of BPC-157 will also be reviewed.

Course Objectives:

  • Describe the history of discovering BPC 157
  • Understand the multiple pathways that BPC 157 activates
  • Formulate a plan in dosing BPC 157 in a musculoskeletal tear.

Cosmeceutical Peptides

Edwin Lee, MD, FACE
Skin aging is a natural process that is caused by intrinsic changes and extrinsic damage. Over time there is a decrease in type 1 collagen, increase in fragmentation of collagen and accumulation of elastin material which causes the skin to wrinkle, increase in age spots, and have a leathery appearance. Growth factors and cytokines have been used in cosmetic products to help with the aging skin. However, with their large size of >15,000 Da limits their ability to penetrate the skin. Peptides offer the advantage of growth factor like activities with better skin penetration due to their smaller molecular size and also with their signaling effects. Several peptides including GHK, Botox like peptides, enzyme peptides and others will be reviewed. Also the pleotrophic effects of GHK copper will be covered.

Course Objectives:

  • Describe the causes of aging skin
  • Review the clinical data on the peptides on improving the aging skin
  • Formulate a plan on using peptides to help the skin look younger

Peptides in Cancer Treatment

Luis Martinez, MD, MPH
Advances in peptide biology have shed light on multiple pathways which can be targeted for therapeutic interventions in the treatment of cancer. These can be incorporated as part of a comprehensive management approach. The lecture will discuss peptide classes, mechanisms of action and proposed protocols for incorporating peptide therapy in the treatment of cancer patients. Immune system and cancer biology will be discussed as they relate to the direct effects of these therapies. Peptides including Met-Enkephalin, PNC 27, P18 and TA1 among others will be discussed. Oncostatic and oncolytic mechanisms of action will be reviewed. Dosing protocols and cases will be presented.

Course Objectives:

  • Review cell growth cycle and relevant checkpoints
  • Detail immune system surveillance for abnormal cancer growth
  • Discuss how the different peptide act on and can inhibit cancer growth

Top 5 Peptides and Peptide QA

Edwin Lee, MD, FACE
Luis Martinez, MD, MPH

Course Objectives:

  • Review the clinical data on the top 5 peptides
  • Panel Discussion
  • Questions and Answers

Immunosenescence

Luis Martinez, MD, MPH

Immunosenescence refers to the gradual accumulation of dysfunctional immune cells brought about by aging and its complications. Targeting immunosenescence has emerged as one of the top strategies in the fight against aging. The lecture will describe in detail immunosenescence, its causes, how it contributes to multiple diseases and how it can be identified and treated clinically.
Objectives:

  • Define immunosenescence
  • Detail how to assess it in a clinical scenario
  • Describe treatment protocols for targeting and treating immunosenescence in aging patients

Peptides in Athletic Performance

Luis Martinez, MD, MPH

An often-seen request by patients, be it “weekend warriors” or elite level athletes, is how and which peptides can be utilized to improve athletic performance. Although the subject of performance enhancement in sports can be controversial and depending on specific scenarios, even illegal, the value of achieving optimal physical fitness as it relates to health and wellness must always be considered. Previously, the focus for improving physical performance rested on hormones, but now peptides have become an option in clinical practice. This lecture will discuss the role of different peptides in improving athletic performance. We will also discuss the regulatory aspects, drug testing, and different protocols that will relate to different types of athletes.

Objectives:

  • List the different peptides that can be used for improving athletic performance
  • Discuss mechanisms of action
  • Differentiate between what regular patients can use vs elite athletes
  • Review what is banned for elite athletes (WADA/USADA testing)
  • Present protocols

Nuts and Bolts in Stem Cells

Luis Martinez, MD, MPH
Stem cell therapies are one of the major components of Regenerative Medicine. It is important for practitioners entering the field to understand the different aspects and applications of stem cell therapies. This presentation will go from reviewing the basic science of stem cells to describing how to harvest stem cells from patients and how to apply them. Additionally, we will go over regulatory aspects, international trends, and off-the-shelf products claiming to have stem cells. Practitioners will leave with a good understanding of the fundamentals needed for integrating these therapies.

Objectives:

  • Understand the basic terminology and biology of stem cells
  • Compare autologous vs allogeneic stem cell therapies
  • Describe harvesting methods for autologous stem cell therapies
  • Review regulatory concerns regarding stem cell therapies
  • Discuss of the shelf products claiming to have stem cells

Understanding Senescence and Senolytic Therapy

Edwin Lee, MD, FACE

We often consider aging as inevitable but aging is the mother of all diseases. Dr. David Sinclair from Harvard and many other scientists have made the link of senescence to aging. Senescence is the permanent cell cycle arrest, or cells stop dividing but do not die. It is the accumulation of the senescence cells that leads to aging and contributes to multiple diseases, including cancer. In this talk, the role of epigenetic and senescence will be discussed, and the clinical trials to reduce senescence (senolytic therapy) will be reviewed.

Objectives

  • Understand what the normal role of senescence
  • Recognize the dangers of accumulation of senescence
  • Review the clinical trials of reducing senescence (senolytic therapy)

Peptides for Pain

Edwin Lee, MD, FACE

The Centers for Disease Control estimates that 50 million Americans have chronic pain and about 20 million have pain severe enough that it frequently limits life of work activities. The current use of narcotic painkillers can be dangerous. Peptides are signaling molecules and are made of amino acids that usually have a length of less than 50 amino acids. The three peptides that will be reviewed for pain are Thymosin Beta 4, BPC 157 and ARA290. Only Thymosin Beta 4 has an FDA orphan drug status and the other 2 are not FDA approved. The science and data will be reviewed on these therapies.

Objectives

  • Understand that narcotic painkillers can be dangerous and very addicting.
  • Understand the difference between Thymosin Beta 4, BPC 157 and ARA 290
  • Recognize that using these peptides are not FDA approved.

Controversy of Insulin Growth Factor

–1 (IGF–1) and longevity
Edwin Lee, MD, FACE

There is a recent controversy on an elevated IGF-1 and longevity in humans. On one side of the argument increasing IGF-1 levels is considered the fountain of youth. Increasing IGF-1 has been shown to help maintain, build and repair muscles and other organs. In addition, increasing IGF-1 improves the immune system, osteoporosis and other conditions that will be reviewed in this talk. The other side of this recent controversy is the association of increased IGF-1 levels with shortened lifespan. In animal models it has been shown that down-regulation of the GH/IGF-1/insulin system significantly prolongs lifespan. In this talk we will review the link of IGF-1 and longevity and the data on human longevity and IGF-1 levels.

Objectives

  • Understand the benefits of increasing IGF-1 in humans.
  • Understand that in animal models that lower IGF-1 has increased longevity and that lower IGF-1 may improve longevity in humans
  • Review of the clinical data on human longevity and IGF-1 levels.

Case Studies of Peptides, Stem Cells and Senolytic Therapy

Edwin Lee, MD & Luis Martinez, MD

This presentation will be done by both Dr. Lee and Dr. Martinez. The peptides of thymosin Beta 4, BPC 157, ARA290, MOTS-c, AOD-9604 and others will be reviewed in case studies ranging from patients with joint pain, osteoarthritis, acute muscle tears and other conditions. A case study of using MOTS-c with obesity and metabolic syndrome will be presented. Other case studies using mesenchymal stem cells will be presented. In addition, case studies of senolytic therapy will be reviewed.

Objectives

  • Understand the dosing used with peptides in joint injections
  • Understand the dosing of senolytic therapy.
  • Understand the dosing used in stem cells.