ABSTRACT Go to section... TOP ABSTRACT INTRODUCTION ALZHEIMER’S DISEASE PARKINSON’S DISEASE NEURODEGENERATIVE DISEASES, PARTIAL AUTOPHAGY, AND AGING NATURAL SUBSTANCES AND NEURODEGENERATIVE DISEASE NATURAL SUBSTANCES THAT ENHANCE AUTOPHAGY (FOR PREVENTION OR TREATMENT OF NEURODEGENERATIVE DISEASE) CONCLUSIONS COMPETING INTERESTS REFERENCES Progressive neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease are a major public health burden. Neurodegenerative diseases have a common pathophysiology of protein aggregate formation but the exact mechanism of neuronal destruction has not been pinpointed. Various theories have been proposed in the literature to explain the underlying causes of these diseases, including reactive oxygen species generation, mitochondrial dysfunction, excessive neuroinflammation, ...Read More
ABSTRACT Hericium erinaceus, most commonly known as lion’s mane, is an edible fungus, with a long history of use in Traditional Chinese Medicine. The mushroom is abundant in bioactive compounds including β-glucan polysaccharides; hericenones and erinacine terpenoids; isoindolinones; sterols; and myconutrients, which potentially have neuroprotective and neuroregenerative properties. Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus mycelium shows great promise for the treatment of Alzheimer’s and Parkinson’s diseases. The fungus was well tolerated in two clinical studies, with few adverse events reported. INTRODUCTION Ancient, traditional, and modern ...Read More
Rosmarinic acid (RosA) is an ester of caffeic acid and 3,4-dihydroxyphenylactic acid. RosA has a number of beneficial biological activities, including antiviral, antibacterial, anti-inflammatory, and antioxidant properties. Oxidative stress is recognized as a common factor in many neurodegenerative diseases and is a proposed mechanism for age-related degenerative processes as a whole. RosA has shown antioxidative action, acting as a scavenger of free radicals. RosA protects neurons from oxidative stress, significantly attenuated hydrogen peroxide-induced reactive oxygen species generation, and apoptotic cell death and could contribute at least in part to neuroprotective effects. RosA has also been shown to suppress immunoglobulin ...Read More
Pulsatilla, Nepeta, and Rauvolfia are important therapeutic agents with nerve-calming effects. Although not as strong as anxiolytic drugs, these herbal remedies are gentle and safe treatments for anxiety and insomnia. They can improve sleep, reduce mood swings and irritability, and moderate the stress-induced ‘fight-or-flight’ state. Theoretical concerns regarding adverse combination with alcohol or other psychoactive drugs have not been confirmed by clinical or scientific studies. The onset of depression must be monitored carefully when prescribing Rauvolfia to pre-disposed patients; however, this side effect does not appear to occur as commonly or severely as previously cited in the literature. AARM ...Read More
It appears that the marked increase in the rate of autism, asthma, and attention deficit with hyperactivity throughout much of the world may be largely caused by the marked increase in the use of acetaminophen in genetically and/or metabolically susceptible children, and the use of acetaminophen by pregnant women. Toxicity of acetaminophen may cause autism by overloading the defective sulfation pathway catalyzed by phenolsulfotransferase, which is deficient in autism, leading to overproduction of the toxic metabolite N-acetyl-p-benzoquinone imine (NAPQI). Increased levels of NAPQI reduce the ability to detoxify a host of toxic chemicals in the environment, increasing oxidative stress, ...Read More
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