Oncology

ABSTRACT The powdered rhizome of turmeric has been extensively used in India and other South Asian cuisines, and is an integral part of Ayurvedic medicine for a broad range of conditions. In particular, curcumin, a major active component of turmeric, is one of the most studied botanicals for its anti-inflammatory, anti-oxidant and anti-cancer properties. Despite its well-documented therapeutic efficacy, for years the limited systemic bioavailability of curcumin has hindered its development as a potential therapeutic agent. However, recent introduction of unique extraction processes and various delivery methods has resulted in the development of new curcumin formulations and significantly improved its ...
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ABSTRACT Reactive oxygen species (ROS) are by-products of metabolism that increase in the body during inflammation, smoking, and exposure to agents such as radiation and certain drugs. ROS cause damage to DNA and other molecules, and they are implicated in the development and progression of cancer. Antioxidants from endogenous and dietary sources can neutralize and destroy ROS and may play a role in cancer prevention. Experimental and animal studies have shown that treatment with single or combined antioxidants prevents neoplastic transformation of normal cells and inhibits tumor growth. Human observational studies suggest that high intake of antioxidant-rich foods, notably fruits, ...
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Objective: To determine if oral artemisinin is safe and has a short-term effect on prostate specific antigen (PSA) kinetics in patients with prostate cancer (CaP). Design: Retrospective case series. Setting: A private naturopathic urology clinic in Seattle, WA. Patients: All artemisinin-treated CaP patients were identified retrospectively between 2005 and 2008. A total of 15 patients were identified who had taken artemisinin and included in the study, comprising 5 patients who had previously undergone radical prostatectomy (RP) and were having biochemical recurrences as well as 10 patients with no prior conventional therapy for CaP. Interventions: High-dose, pulsed oral artemisinin 300‐400 mg ...
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OBJECTIVE: To review the current literature regarding vitamin D insufficiency and supplementation in major illnesses. DESIGN AND METHODS: We reviewed Pubmed-indexed, English language manuscripts from January, 2003 to June, 2012 using search terms related to vitamin D, all-cause mortality, cardiovascular disease, pulmonary disease, diabetes mellitus, and cancer. OUTCOME MEASURES: Incidence of disease, risk ratios associated with 25-hydroxyvitamin D [25(OH)D] levels, and/or vitamin D supplementation schedules were documented. RESULTS: Although 25(OH)D levels ≥20 ng/mL were often associated with improved health outcomes, evidence suggests that 25(OH)D levels ≥30 ng/mL may confer additional health benefits. CONCLUSIONS: Based on the available evidence, vitamin ...
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