What to Tell Your Patients: A Critical Review of the JAMA Cardiology Meta-Analysis “Associations of Omega-3 Fatty Acid Supplement use with Cardiovascular Disease Risks”

Authors of a meta-analysis recently published in JAMA Cardiology concluded that omega-3 fatty acids have no significant association with fatal or nonfatal coronary heart disease or any major vascular events. This critical review examines participant profile, intervention dosage, bioavailability of intervention, and duration of therapy for the cited trials and determines that the conclusion of the meta-analysis is tentative at best.