What to Tell Your Patients: A Critical Review of the JAMA Cardiology Meta-Analysis “Associations of Omega-3 Fatty Acid Supplement use with Cardiovascular Disease Risks”

Authors of a meta-analysis recently published in JAMA Cardiology concluded that omega-3 fatty acids have no significant association with fatal or nonfatal coronary heart disease or any major vascular events. This critical review examines participant profile, intervention dosage, bioavailability of intervention, and duration of therapy for the cited trials and determines that the conclusion of the meta-analysis is tentative at best.

Letter From the Editor

Volume 6 of this Journal is a strong statement of our on-going commitment to provide the highest quality information in the form of research, clinical findings, and insights about restorative medicine to those who practice it, and who seek to ground what they do in a solid evidence base. This issue includes original research and several clinically oriented review articles.

Neurological Activity of Lion’s Mane (Hericium erinaceus)

Because of its anti-inflammatory properties and promotion of nerve growth factor gene expression and neurite (axon or dendrite) outgrowth, H. erinaceus mycelium shows great promise for the treatment of Alzheimer’s and Parkinson’s diseases.

The Holy Grail of Curcumin and its Efficacy in Various Diseases: Is Bioavailability Truly a Big Concern?

This article dissects various contributing factors of curcumin bioavailability to identify possible causes for the discrepancies associated with its bioactivity and discuss how these new curcumin formulations could further improve its clinical usefulness.

Evaluation of Case Report Publications on Naturopathic Medicine

The aims of this article are to evaluate case report publications on naturopathic medicine and to suggest improvement in the content of these case reports to ensure that they appropriately capture the philosophical underpinnings of this type of medicine.

Iodine or Iodide? A Laboratory Evaluation of the Content of ­Powdered Iodine Supplements

Some proponents of supplementation believe that products containing both iodine and iodide are therapeutically superior to iodide-only formulations. As a step toward evaluating this claim, we tested three commercially available products that list both iodine and iodide on the label, to determine their content.