Autoimmune diseases are a group of disorders in which the immune system dysfunctions and attacks host tissues. Although the pathogenesis of autoimmune thyroid disease has not been elucidated, there are several factors that have been associated with the disorder. Factors include genetic predisposition, nutrient deficiencies, use of certain medications affecting thyroid function, and environmental factors including exposure to radiation, heavy metals, and chemical contaminants. Thyroid disorders are often treated with drug therapy, which often have serious side effects and do not necessarily treat the underlying condition leading to the thyroid dysfunction. In recent years there has been increased interest ...
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An epigenetic influence on many chronic and metabolic diseases is now well-established, in some cases with a larger effect on disease risk and susceptibility than many well-established risk factors. Additionally, the evidence base for the role of persistent organic pollutants in many of these same diseases has grown considerably, and it appears that the toxic effects of these substances are mediated in part via epigenetic mechanisms, particularly during critical periods of development. Here we review the associations between these long-lasting toxins and today’s highly prevalent diseases, the epigenetic pathways, as well as suggested interventions to mitigate their harm. INTRODUCTION ...
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Glutathione (GSH), the most abundant intracellular low molecular weight thiol, has diverse physiological roles, and altered GSH status has been implicated in a number of chronic, acute, and age-related diseases, as well as the aging process itself. Its function as an antioxidant and determinant of cellular redox potential is crucial both for protection from reactive oxygen species as well as a signaling molecule involved in cellular proliferation, cell cycle regulation, and apoptosis. It is also an important thiol buffer, maintaining sulfhydryl groups in their reduced form, an additional mechanism for cellular signaling. Glutathione has also emerged a key modulator ...
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