Indications Anxiety, insomnia, restlessness, tension, and pain syndromes. Mechanism of Action The neurophysiological activities of Piper methysticum are attributed primarily to the lipophilic resinous compounds, known as kavalactones (also known as kava pyrones), found in the root. To date, 18 different kavalactones have been identified; however, approximately 96% of the…
Indications Adrenal fatigue, anxiety, and insomnia. Mechanism of Action The withanolides, a group of steroidal lactones, are credited with adrenal supportive effects.1 Steroidal compounds in plants are structurally similar to human steroids, and many are noted to have numerous physiological effects. Animal studies suggest that ashwagandha is a γ-aminobutyric acid…
Indications Insomnia and possibly nervousness and anxiety. Mechanism of Action Several constituents of Valeriana officinalis have been found to have sedative or anxiolytic properties. These constituents are valerenic acid (VA), 6-methylapigenin (MA), (2S)-hesperidin (HN), and the flavonoid glycoside linarin (LN). VA and MA have been shown to have GABAergic activity.…
Indications Insomnia, anxiety, and nervous tension. Mechanism of Action The above-ground parts, principally the leaves and flowers, are used medicinally. Two important flavonoids found in Scutellaria are baicalin and wogonin. They are thought to be GABAergic, binding to the benzodiazepine site of the γ-aminobutyric (GABA) receptor, and thereby have a…
Related Species Rhodiola imbricate, Rhodiola sachalinensis. Indications An adaptogen used to help the body adapt to physical, mental, and environmental stresses; increase energy, stamina, strength, and mental capacity; improve athletic performance and sexual function; and balance mood for depressive and anxious states. Mechanism of Action Rhodiola root contains phenylpropanoids and…
