The Role of Selenium in Thyroid Autoimmunity: A Review

Abstract Autoimmune thyroid diseases, including Graves’ disease and Hashimoto’s thyroiditis, are the most common autoimmune conditions in humans. There is significant morbidity associated with thyroid autoimmunity, and typically ongoing management is required to control disease presentation and reduce sequelae. Thyroid tissues contain the highest concentration of selenium in the body,…

Nutrigenomics, Metabolic Correction and Disease: The Restoration of Metabolism as a Regenerative Medicine Perspective

Abstract Nutrigenomics is the study of the effects of food and food constituents on gene expression. The study of nutrigenomics may have a major impact in the development of tailor-made food, supplements and beverage products in the near future. The “genetic nutritioneering” concept summarizes the information on how diet, supplements,…

Synergy in Herbal Medicines

Abstract In the following paper, we will review the available literature on synergy and additive effects involving medicinal herbs and herbal extracts. Several types of synergistic interactions are discussed, including apparently inactive constituents enhancing the effects of apparently active constituents within and between herbal medicines, various herbal compounds altering the…

The Effect of Rosmarinic Acid on Immunological and Neurological Systems: A Basic Science and Clinical Review

Abstract Rosmarinic acid (RosA) is an ester of caffeic acid and 3,4-dihydroxyphenylactic acid. RosA has a number of beneficial biological activities, including antiviral, antibacterial, anti-inflammatory, and antioxidant properties. Oxidative stress is recognized as a common factor in many neurodegenerative diseases and is a proposed mechanism for age-related degenerative processes as…

Extra-Thyroidal Factors Impacting Thyroid Hormone Homeostasis: A Review

Abstract Peripheral metabolism plays a significant role in maintaining thyroid hormone expression in local tissues. The thyroid secretes thyroxine (T4) at substantially greater levels than triiodothyronine (T3), relying on peripheral mechanisms to convert T4 to T3. Peripheral control is exerted through a number of pathways. These pathways include deiodination, facilitated…

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