Indications Allergic rhinitis, musculoskeletal disease such as osteoarthritis, urinary tract infections and inflammation, kidney stones, anemia, diabetes, thyroid disease, and other endocrine disorders. Also, a source of vitamins A, C, and K; potassium; phosphorus; and calcium. Mechanism of Action Flavonoids in Urtica dioica have demonstrated anti-inflammatory1 and antioxidant effects,2 particularly…
Indications Hyperthyroidism and hyperthyroid-like symptoms including anxiety and insomnia, and Grave’s disease. Mechanism of Action When thyroid-stimulating hormone (TSH) binds to the outer membrane of thyroid cells, it triggers a cAMP response on the inside of the cell via adenylate cyclase enzyme activation. Melissa extracts interfere with the binding of…
Indications Hyperthyroidism and hyperthyroid-like symptoms including heart palpitations, tachycardia, chest tightness, tremor, and anxiety. Mechanism of Action Lycopus contains rosmarinic acid, a phenolic compound derived from caffeic acid and found in several other Lamiaceae plants, all indicated historically for the symptoms of hyperthyroidism. Rosmarinic acid, and the related lithospermic and…
Related Species The Phseophyceae (brown algae) are a large class of mostly marine multicellular algae that include many dietary and medicinal seaweeds, including kombu (Saccharina japonica), Fucus vesiculosis, and others. Indications Used as an iodine source for hypothyroidism with goiter attributable to iodine and other mineral deficiencies, hyperlipidemia, and obesity.…
Indications Goiter (may be administered both topically and internally), sluggish metabolic function, detoxification (especially the thyroid gland), promote movement of sluggish body fluids including saliva, lymph, bile, and digestive secretions. Mechanism of Action Iris contains iridin, an isoflavone. Iridin is the 7-glycoside of irigenin that can be isolated from several…
Indications Goiter and thyroid disease (including hypo- and hyperthyroid states), obesity, and cancer. Mechanism of Action Fucus has a high halide mineral content, including iodine, which has good bioavailability,1 and selenium, which is of central importance in regulation of the thyroid gland.2 The presence of iodine and specific selenoproteins implicated…
Related Species Commiphora molmol & Commiphora madagascariensis – myrrh (oleo gum resin) Commiphora abyssinica & Commiphora habessinica – Abyssinian myrrh Indications Thyroid conditions such as hypothyroidism and subclinical hypothyroidism, Hashimoto's and Wilson's Temperature Syndrome. Inflammatory conditions such as arthritis, hypercholesterolemia with lipid peroxidation and atherosclerosis. Mechanism of Action Guggul seems…
Iodine is an essential trace mineral that is necessary for thyroid hormone production. With the prevalence of iodine deficiency worldwide, universal salt iodization programs were successfully implemented to reduce the incidence of iodine deficiency disorders; however, unexpected increases in the prevalence of thyroid autoimmunity occurred, and iodine excess was implicated as the causative factor. Despite these observations, epidemiological studies are inconsistent, and the etiology of autoimmune thyroid disease remains undefined. A review of observational and in vitro studies revealed that iodine alone is not responsible for thyroid autoimmunity.
Obesity is a major issue in developed countries. Regulating thyroid hormones is a growingly popular adjunct in a comprehensive approach towards weight loss. Despite growing popularity, there is a lack of knowledge about underlying pathways. This review investigates the thermogenic properties of thyroid hormone on brown adipose tissue (BAT), white…
Abstract Autoimmune thyroid diseases, including Graves’ disease and Hashimoto’s thyroiditis, are the most common autoimmune conditions in humans. There is significant morbidity associated with thyroid autoimmunity, and typically ongoing management is required to control disease presentation and reduce sequelae. Thyroid tissues contain the highest concentration of selenium in the body,…
Abstract Peripheral metabolism plays a significant role in maintaining thyroid hormone expression in local tissues. The thyroid secretes thyroxine (T4) at substantially greater levels than triiodothyronine (T3), relying on peripheral mechanisms to convert T4 to T3. Peripheral control is exerted through a number of pathways. These pathways include deiodination, facilitated…
Abstract New research is demonstrating that thyroid hormone transport across cellular membranes plays an important role in intracellular triiodothyronine (T3) levels of peripheral and pituitary tissues and is proving to have considerable clinical significance. Reduced T4 and T3 transport into the cells in peripheral tissues is seen with a wide…
